Skip Navigation Links
Centers for Disease Control and Prevention
nav image
nav image CDC Home Search Health Topics A-Z
Public Health Emergency Preparedness & Response
Links to Home and Contact Us
Public Health Emergency Preparedness & Response Home Search Contact Us
Department of Health and Human Services
Site Contents
En Español
Public Inquiries
English (888) 246-2675
Español (888) 246-2857
TTY (866) 874-2646
Mon-Fri 8am-11pm EST
Sat-Sun 10am-8pm EST

Centers for Disease Control and Prevention
1600 Clifton Rd.
Atlanta, GA 30333
USA
(404) 639-3311
FirstGov
Chemical Agents > Ricin >

NIOSH EMERGENCY RESPONSE CARD

 

BIOTOXIN

RICIN

Click for Printable Version

UN #: 3172 GUIDE 153

CAS #: 9009-86-3
Alternate CAS #: 9067-26-9

RTECS #: VJ2625000

Ricine
Ricinus lectin
Ricinus agglutinin
Ricinus toxin
Lectin isolated from seeds of the castor bean
Ricinus communis protein/polypeptide

Chemical Formula: N/A

Molecular mass: N/A
 

TYPES OF
HAZARD/
EXPOSURE

ACUTE HAZARDS/
CLINICAL SIGNS/
SYMPTOMS

PREVENTION/
PERSONAL PROTECTIVE EQUIPMENT

FIRST AID/
FIRE FIGHTING

FIRE

N/A

Avoid generating dust.

Foam, dry chemical powder, BCF (where regulations permit), carbon dioxide, water spray or fog - large fires only.

EXPLOSION

N/A N/A
 
N/A

ROUTE OF
EXPOSURE

Synopsis:

Extremely Toxic. May be Fatal.

Ricin (and Abrin) cause toxicity by inhibition of protein synthesis.

May cause severe allergic reactions.

AVOID ALL CONTACT.

STRICT HYGIENE!

May adhere to skin or clothing.

Seek medical attention immediately.

Inhalation:

May cause severe lung damage in humans (based on reports of exposure in animals.) Repeated exposure in humans is known to cause allergic/asthma-like symptoms including congestion of the nose and throat, itchyness of the eyes, hives, tightness of the chest, and in severe cases, wheezing.

(See Ingestion for other symptoms.)

Pressure demand, self-contained breathing apparatus (SCBA) (SCBA CBRN, if available) is recommended in response to non-routine emergency situations.

Breath Response (pressure demand) HEPA PAPR

See CDC/NIOSH Interim Recommendations.

Fresh air, rest. Half-upright position. If breathing is difficult, administer oxygen. Perform CPR if necessary.

Seek medical attention immediately.

Skin:

Potential for allergic skin reaction; redness, blisters, pain.

May be absorbed!

Tychem® BR or Responder® CSM protective clothing. Eyes should be protected when possible.

Remove contaminated clothes. Rinse skin with plenty of water or shower (and soap if available).

Seek medical attention immediately.

Eyes:

Tearing, swelling of the eye-lids, pain, redness, corneal injury.

Goggles with respiratory protection or full face-piece respirator.

Immediately flush with large amounts of tepid water for at least 15 minutes.

Seek medical attention immediately.

Ingestion:

Symptoms are rapid in onset (generally less than a few hours) following ingestion.

  • Nausea, vomiting, abdominal pain and cramping.
  • Diarrhea
  • Gastrointestinal Bleeding
  • Low or no urinary output
  • Dilation of the Pupils
  • Fever
  • Thirst
  • Sore Throat
  • Headache
  • Vascular collapse and shock
Do not eat, drink, or smoke during work. Wash hands before eating. May be fatal. However, the death rate even among symptomatic patients is generally low. Do not induce vomiting. Rinse mouth. Use slurry of activated charcoal. If individual is drowsy or unconscious, do not give anything by mouth. In the event of vomiting, lean patient forward or place on left side (head-down position, if possible) to maintain open airway and prevent aspiration. Early and aggressive IV fluid and electrolyte replacement.

Seek medical attention immediately.


OCCUPATIONAL EXPOSURE LIMITS (OELs)

OSHA PEL: N/A
NIOSH REL: N/A
ACGIH TLV: N/A
ChemWatch: Ceiling: 0.00006 (sensitizer) mg/m3
NIOSH IDLH: N/A

SAMPLING AND ANALYTICAL METHODS

NIOSH: N/A

OSHA: N/A
 

DECONTAMINATION

Patient/Victim: Wash with soap and water. Work clothes should be laundered separately. Launder contaminated clothing before re-use. Do not take clothing home.

Equipment: N/A

Environment: Use dry clean up procedures (e.g. hepa vacuum) and avoid generating dust. (see Spillage Disposal.)

SPILLAGE DISPOSAL

Polyethylene or polypropylene container.

Keep containers securely sealed when not in use.

Store in a cool, dry, well-ventilated area and away from food stuff containers.

PACKAGING & LABELLING

 

UN#: 3172 (GUIDE 153)

Proper Shipping Name: N/A
Hazard Class: 6.1(a)
Packing Group: I
    NFPA 704 Signal:

    Health - N/A
    Flammability - N/A
    Reactivity - N/A
    Special - N/A
 

IMPORTANT DATA

PHYSICAL STATE; APPEARANCE:
White powder.

PHYSICAL DANGERS:
Product is considered stable. Avoid contact with oxidizing agents.

CHEMICAL DANGERS:
Hazardous polymerization will not occur.

ROUTES OF EXPOSURE:
Can be absorbed by all routes of exposure.

INHALATION RISK:
Irritation, sensitization.

EFFECTS OF SHORT-TERM EXPOSURE:
Severe vomiting and diarrhea may result in severe dehydration (hypovolemic-shock) and multisystem organ failure: effects on GI tract, kidney, liver, and pancreas. Potentially fatal due to severe allergic reaction.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Allergic syndrome with congestion of nose and throat; itchy, watery eyes; hives; tightness of the chest; and in severe cases - wheezing.

PHYSICAL
PROPERTIES

Melting Point: N/A

Boiling Point: decomposes (See Additional Information.)
Vapor Pressure (20°C): Negligible
Density (20°C): N/A
Volatility: Negligible
Specific gravity: N/A
Aqueous solubility(20°C): soluble
Soluble: 10% NaCl solution estimated log Kow: N/A
Flashpoint: N/A

Flammability: N/A

ENVIRONMENTAL
DATA

 

ACUTE EXPOSURE
GUIDELINES (AEGLs)

  10 min 30 min 1hr 4 hr 8 hr
AEGL 1 (discomfort, non-disabling) N/A N/A N/A N/A N/A
AEGL 2 (irreversible or other serious, long-lasting effects or impaired ability to escape) N/A N/A N/A N/A N/A
AEGL 3 (life-threatening effects or death)
N/A N/A N/A N/A N/A

NOTES

Lethal dose = 1 mg/kg. Urinary excretion of ricin is probably slow and limited with the estimated half-life being about 8-days. Oral exposure to ricin appears to be less toxic than by other routes of exposure.
 

ADDITIONAL
INFORMATION

Ricin is detoxified in 10 mins at 176°F (80°C) and in 1 hr at 122°F (50°C); it is stable under ambient conditions.

 

GLOSSARY OF ACRONYMS

APR - Air-purifying Respirator
CBRN -
Chemical, Biological, Radiological, Nuclear
IDLH -
Immediately Dangerous to Life and Health
REL -
Recommended Exposure Limit
PEL -
Permissible Exposure Limit
SCBA - Self-Contained Breathing Apparatus

 

IMPORTANT
NOTICE:

RICIN (ERC9009-86-3) The user should verify compliance of the cards with the relevant STATE or TERRITORY legislation before use. NIOSH, CDC 2003.

 

 Top of Page


Home | Search | Contact Us

CDC Home | Search CDC | Health Topics A-Z

In general, all information presented in these pages and all items available for download are for public use. However, you may encounter some pages that require a login password and ID. If this is the case, you may assume that information presented and items available for download therein are for your authorized access only and not for redistribution by you unless you are otherwise informed.

Page last modified April 24, 2003

Privacy Policy | Accessibility